Embryotoxic effects of eight organic peroxides and hydrogen peroxide on three-day chicken embryos

Journal Article · Wed Feb 01 04:00:00 EST 1984 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(84)90008-2· OSTI ID:6903233

Korhonen, A; Hemminki, K; Vainio, H

Nine peroxides used in rubber processing were tested for embryotoxicity in 3-day chicken embryos using the air chamber method. The potencies were expressed by the ED/sub 50/ for the total embryotoxic effect of the chemicals, including deaths and malformations, up to Day 14 of the incubation. The range of the ED/sub 50/'s was from 0.13 to 2.7 ..mu..moles per egg and the order of the potencies was as follows: cyclohexanoneperoxide > cumolhydroperoxide > ethylmethylketoneperoxide > dibenzoylperoxide > acetylacetoneperoxide > perbenzoic acid-tert-butylester > dicumylperoxide > dialauroylperoxide > hydrogen peroxide. All nine peroxides caused malformations at a moderate frequency. The maximum percentage of malformed embryos of the treated varied from the 16% of perbenzoic acid-tert-butylester to the 56% of dicumylperoxide. The high percentage caused by the latter could, however, result from slow diffusion of high lethal doses from the air chamber to the embryo.

• Research Organization: Inst. of Occupational Health, Helsinki, Finland
• OSTI ID: 6903233
• Journal Information: Environ. Res.; (United States), Journal Name: Environ. Res.; (United States) Vol. 33:1; ISSN ENVRA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIRDS
CHICKENS
EMBRYOS
FOWL
MORTALITY
OXYGEN COMPOUNDS
PEROXIDES
SCREENING
SENSITIVITY
TERATOGEN SCREENING
TERATOGENESIS
VERTEBRATES