Incorporation of stable and radioactive isotopes via organoborane chemistry

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Acc. Chem. Res.; (United States)

DOI:https://doi.org/10.1021/ar00102a003· OSTI ID:6900935

Kabalka, G W

An organic synthesis involving the use of organoboranes rather than the traditional substitution reactions and Grignard reagents for the rapid preparation of physiologically active materials labelled with short-lived isotopes is discussed in detail. The iodination reaction for incorporating I-123 or I-125 into compounds was found to proceed via an electrophilic attack by the iodine molecule on the electron-rich borax complex, did not require the presence of strong base, and was complete in 60 sec. The procedure also uses radiolabeled NaI rather than the more unstable iodine monochloride usually used. A similar procedure was developed for labelling compounds with Br-77. Other direct one-pot syntheses are described for incorporation of O-17, N-13, N-15, C-11, and C-13 into compounds very rapidly.

• Research Organization: Univ. of Tennessee, Knoxville
• OSTI ID: 6900935
• Journal Information: Acc. Chem. Res.; (United States), Journal Name: Acc. Chem. Res.; (United States) Vol. 17:6; ISSN ACHRE
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400702* -- Radiochemistry & Nuclear Chemistry-- Properties of Radioactive Materials
550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BORANES
BORON COMPOUNDS
BROMINE 77
BROMINE ISOTOPES
CARBON 11
CARBON ISOTOPES
CHEMICAL PREPARATION
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE 125
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MINUTES LIVING RADIOISOTOPES
NITROGEN 13
NITROGEN 15
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
OXYGEN 17
OXYGEN ISOTOPES
RADIOCHEMISTRY
RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TRACER TECHNIQUES