Rapid and mild syntheses of radioiodine-labeled radiopharmaceuticals
Journal Article
·
· J. Nucl. Med.; (United States)
OSTI ID:5610936
Radioiodine-labeled pharmaceuticals have been used extensively in diagnostic nuclear medicine. We have developed a rapid and mild method for incorporating radioiodine into functionally substituted molecules. The new process involves the reaction of the radioiodide ion with organoboranes in the presence of gentle oxidizing reagents. The radioiodide is utilized nearly quantitatively in a matter of seconds. The radiochemical yields are excellent, and parallel those obtained when iodine monochloride is reacted with organoboranes.
- Research Organization:
- University of Tennessee, Knoxville
- OSTI ID:
- 5610936
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:10; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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