Enriched xenon-124 for the production of high purity iodine-123 using a CP-42 cyclotron

Conference · Sat Dec 31 23:00:00 EST 1983 · J. Nucl. Med.; (United States)

OSTI ID:6898849

Graham, D; Trevena, I C; Webster, B; Williams, D

The preferred production route for I-123 is that employing the I-127 (p,5n) reaction. This reaction requires energies beyond the capabilities of compact industrial cyclotrons. The possibility of using the reactions Xe-124 (p,2n)Cs-123 ..-->.. Xe-123..-->.. I-123, and Xe-124 (p,pn)Xe-123 ..-->.. I-123 was investigated using xenon containing 50% Xe-124. Three xenon gas targets were evaluated on an external beamline of the CP-42 cyclotron installed at TRIUMF in Vancouver. Two of these targets performed routinely with beam currents of 75..mu..A and one of these has been tested satisfactorily with natural xenon with a beam current of 150..mu..A. The targets have been relatively thin, about 1-2 MeV, with an incident proton energy of 24-26 MeV. The maximum production from a single run has been 1.1Ci I-123 at the end of chemical processing. I-125 is formed from Xe-126 present in the target gas. Because the half life of Xe-125 is 17h compared with 2h for Xe-123, the I-125 content is dependant upon the length of the irradiation and time that the target gas is allowed to decay prior to processing. With optimum timing, the I-125 content is less than 0.2% at the end of processing. I-123 is washed from the target with dilute base. Since 50% Xe-124 costs about U.S.$130/ml, processing procedures and equipment design must ensure negligible losses. This demonstration of a route for the production of I-123 will enable those with access to a compact cyclotron with an external beamline to produce ''(p,5n)'' quality I-123 using a Xe-124 gas target.

• Research Organization: Atomic Energy of Canada Ltd., Vancouver
• OSTI ID: 6898849
• Report Number(s): CONF-840619-
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 25:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
400700 -- Radiochemistry & Nuclear Chemistry
651720* -- Nuclear Properties & Reactions
A=90-149
Experimental
73 NUCLEAR PHYSICS AND RADIATION PHYSICS
ACCELERATORS
BARYON REACTIONS
BEAM CURRENTS
BEAMS
BETA DECAY RADIOISOTOPES
CHARGED-PARTICLE REACTIONS
CHEMICAL PREPARATION
CHEMICAL REACTION YIELD
COST
CURRENTS
CYCLIC ACCELERATORS
CYCLOTRONS
DIAGNOSTIC USES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
HADRON REACTIONS
HALF-LIFE
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOCHRONOUS CYCLOTRONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPE PRODUCTION
ISOTOPES
LABELLED COMPOUNDS
NUCLEAR REACTIONS
NUCLEI
NUCLEON BEAMS
NUCLEON REACTIONS
ODD-EVEN NUCLEI
PARTICLE BEAMS
PROTON BEAMS
PROTON REACTIONS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SECONDS LIVING RADIOISOTOPES
STABLE ISOTOPES
SYNTHESIS
TARGETS
TRACER TECHNIQUES
TRIUMF CYCLOTRON
USES
XENON 124
XENON 124 TARGET
XENON 125
XENON ISOTOPES
YIELDS