Pancreatic polypepetide inhibits pancreatic enzyme secretion via a cholinergic pathway
- Univ. of Michigan Medical Center, Ann Arbor (USA)
In rat pancreatic slices, rat pancreatic polypeptide (PP) or C-terminal hexapeptide of PP (PP-(31-36)) inhibited potassium-stimulated amylase release in a dose-dependent manner. The inhibition was unaffected by addition of hexamethonium but blocked by atropine. In contrast, PP-(31-36) did not have any effect on acetylcholine- or cholecystokinin octapeptide-stimulated amylase release. In addition, when pancreatic slices were incubated with ({sup 3}H)choline, PP-(31-36) inhibited the potassium-evoked release of synthesized ({sup 3}H)acetylcholine in a dose-dependent manner. The inhibitory action of PP was unaffected by adrenergic, dopaminergic, or opioid receptor antagonists. Thus PP inhibits pancreatic enzyme secretion via presynaptic modulation of acetylcholine release. This newly identified pathway provides a novel mechanism for hormonal inhibition of pancreatic enzyme secretion via modulation of the classic neurotransmitter function.
- OSTI ID:
- 6896913
- Journal Information:
- American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 253:5; ISSN 0002-9513; ISSN AJPHA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ACETYLCHOLINE
ALCOHOLS
ALKALOIDS
AMINES
AMMONIUM COMPOUNDS
AMYLASE
ANIMALS
ATROPINE
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
CHOLINE
DIGESTIVE SYSTEM
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENDOCRINE GLANDS
ENZYMES
ESTERS
GLANDS
GLYCOSYL HYDROLASES
HYDROGEN COMPOUNDS
HYDROLASES
HYDROXY COMPOUNDS
INHIBITION
KININS
LIPOTROPIC FACTORS
MAMMALS
NEUROREGULATORS
O-GLYCOSYL HYDROLASES
ORGANIC COMPOUNDS
ORGANS
PANCREAS
PARASYMPATHOLYTICS
PARASYMPATHOMIMETICS
PEPTIDES
POLYPEPTIDES
PROTEINS
QUATERNARY COMPOUNDS
RATS
RODENTS
SECRETION
SYNTHESIS
TRITIUM COMPOUNDS
VERTEBRATES