Action of a new cholinergic agonist, aclatonium napadisilate, on isolated rat pancreatic acini

Journal Article · Sun Jul 01 00:00:00 EDT 1990 · Pancreas; (USA)

DOI:https://doi.org/10.1097/00006676-199007000-00009· OSTI ID:6532041

Fujii, M; Okabayashi, Y; Nakamura, T; Tani, S; Fujisawa, T; Otsuki, M ^[1]

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1. Kobe Univ. School of Medicine (Japan)

The effect of aclatonium napadisilate, a newly synthesized choline ester, on pancreatic exocrine function was compared with that of the muscarinic agonist carbamylcholine in isolated rat pancreatic acini. Both compounds increased amylase release and {sup 45}Ca{sup 2+} efflux in a dose-dependent fashion, and similarly decreased the binding of (N-methyl-{sup 3}H)scopolamine to isolated rat pancreatic acini. While aclatonium napadisilate was 20-30 times less potent than carbamylcholine in stimulations of amylase release and {sup 45}Ca{sup 2+} efflux, the potency of aclatonium napadisilate in inhibiting (N-methyl-{sup 3}H)scopolamine binding was nearly the same as that of carbamylcholine. These results indicate that aclatonium napadisilate stimulates pancreatic exocrine secretion via muscarinic receptors and Ca{sup 2+} mobilization, and its intrinsic activity is less than carbamylcholine in the isolated rat pancreatic acini. Since aclatonium napadisilate is known to increase motility and peristalsis of the gastrointestinal tract, stimulatory effects of aclatonium napadisilate, shown in the present study, on digestive enzyme secretion from the pancreas may provide additional benefit of aclatonium napadisilate in the treatment of various gastrointestinal disorders.

• OSTI ID: 6532041
• Journal Information: Pancreas; (USA), Journal Name: Pancreas; (USA) Vol. 5:4; ISSN PANCE; ISSN 0885-3177
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALKALINE EARTH ISOTOPES
ALKALINE EARTH METAL COMPOUNDS
AMYLASE
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL FUNCTIONS
BODY
CALCIUM 45
CALCIUM COMPOUNDS
CALCIUM ISOTOPES
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ENDOCRINE GLANDS
ENZYMES
EVEN-ODD NUCLEI
FUNCTIONS
GLANDS
GLYCOSYL HYDROLASES
HYDROLASES
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MEMBRANE TRANSPORT
NUCLEI
O-GLYCOSYL HYDROLASES
ORGANS
PANCREAS
PARASYMPATHOMIMETICS
RADIOISOTOPES
RATS
REACTION KINETICS
RODENTS
TRACER TECHNIQUES
VERTEBRATES