Immediate effect of irradiation on microvasculature

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(88)90359-8· OSTI ID:6895843

Krishnan, L; Krishnan, E C; Jewell, W R

The immediate effects of irradiation on microvasculature in muscle in an animal model are described in this paper. By using triple isotopes of /sup 125/I, /sup 131/I, and /sup 22/Na, the transcapillary transfer of albumin from the vascular bed to the extravascular space is determined in terms of mg/g of tissue, after single doses of 2 to 14 Gy. These results reveal an increase in the extravascular albumin immediately after irradiation and suggest an instantaneous compromise in vascular permeability even after 2 Gy. This effect was apparently dose related.

• Research Organization: Univ. of Kansas College of Health Sciences and Hospital, Kansas City (USA)
• OSTI ID: 6895843
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 15:1; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALBUMINS
ALKALI METAL ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MODELS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
CAPILLARIES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOTOPES
LIGHT NUCLEI
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PERMEABILITY
PROTEINS
RABBITS
RADIATION EFFECTS
RADIOISOTOPES
SODIUM 22
SODIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES