Plutonium in (/sup 99m/Tc) pertechnetate for clinical use: concise communication
Pertechnetate from 31 different Tc-99m generators was analyzed to determine if ..cap alpha..-emitting radionuclides were present. Significant amounts of Pu(239 + 240) were found in the pertechnetate eluted from neutron-activated molybdenum distributed by one manufacturer. The Pu(239 + 240)/Tc-99m activity ratio in the first eluate from these generators varied between 1.3.10/sup -12/ and 1.4.10/sup -11/. The Pu(239 + 240) contamination is believed to originate from uranium impurities in the molybdenum batch. The build-up of Am-241, the daughter decay product of Pu-241, has also been demonstrated. The estimated Pu-241/Pu(239 + 240) activity ratio at the reference time was 8:1. It is strongly recommended that upper limits for the plutonium content of eluates from nonfission-produced molybdenum should be included in the various pharmacopoeias and that restrictions be placed on the uranium content of molybdenum used for the production of Mo-99 by neutron activation.
- Research Organization:
- Malmoe General Hospital, Sweden
- OSTI ID:
- 6887329
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 21:11; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ACTIVATION ANALYSIS
ALPHA DECAY RADIOISOTOPES
BARYONS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHEMICAL ANALYSIS
DAYS LIVING RADIOISOTOPES
DRUGS
ELEMENTARY PARTICLES
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FERMIONS
FISSION PRODUCTS
FISSION RATIO
HADRONS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
IMPURITIES
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
MOLYBDENUM 99
MOLYBDENUM ISOTOPES
NEUTRONS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
PERTECHNETATES
PLUTONIUM 239
PLUTONIUM 240
PLUTONIUM ISOTOPES
QUANTITATIVE CHEMICAL ANALYSIS
QUANTITY RATIO
RADIOACTIVE MATERIALS
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIOPHARMACEUTICALS
TECHNETIUM 99
TECHNETIUM COMPOUNDS
TECHNETIUM ISOTOPES
TRANSITION ELEMENT COMPOUNDS
YEARS LIVING RADIOISOTOPES