Evaluation of (/sup 18/F)-4-fluoroantipyrine as a new blood flow tracer for multiradionuclide autoradiography

Journal Article · Fri Jun 01 00:00:00 EDT 1984 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1984.35· OSTI ID:6885959

Sako, K; Diksic, M; Kato, A; Yamamoto, Y L; Feindel, W

This article reports the evaluation of (/sup 18/F)-4-fluoroantipyrine (FAP) as a quantitative blood flow tracer by comparing blood flow measured with (/sup 18/F)FAP to that determined simultaneously with (/sup 14/C)-4-iodoantipyrine (IAP), a standard blood flow tracer, by means of double-tracer autoradiography. The single-pass extraction value (m), which indicates diffusibility of a tracer, was determined according to the procedure described by Crone. The diffusibility of FAP was essentially the same as that of IAP. The brain-blood partition coefficient for FAP was found to be similar to that for IAP, 0.89 +/- 0.01. Values of local cerebral blood flow obtained with FAP agree with those determined with IAP. From these results, we concluded that FAP is indeed as good a blood flow tracer as IAP. Since /sup 18/F is a positron-emitting radionuclide, it might be a useful tracer for blood flow measurement by positron emission tomography.

• Research Organization: Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
• OSTI ID: 6885959
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Vol. 4:2
• Country of Publication: United States
• Language: English

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