Effect of prenatal ionizing radiation on the visual cortex and hippocampus of newborn squirrel monkeys. [/sup 60/Co]
Five squirrel monkeys were exposed to 200 rads whole-body ionizing irradiation (/sup 60/Co) at 0.4 rads per second on approximately the seventy-fifth day of gestation, and six squirrel monkeys were sham-irradiated. The mean cortical depth and the mean number of neurons per mm/sup 3/ in the visual cortex was less in irradiated animals than in controls, but the differences were not statistically significant. The mean number of glial cells in this cortical region was significantly lower in the irradiated animals. In the hippocampus, the depth of the stratum oriens and the combined depth of the strata radiatum, lacunosum, and moleculare were significantly less in irradiated than in control animals. Canonical correlations provided statistical evidence for greater radiation vulnerability of the hippocampus compared to motor and visual areas of the cerebral cortex.
- Research Organization:
- Tulane Univ., Covington, LA
- OSTI ID:
- 6880286
- Journal Information:
- J. Neuropathol. Exp. Neurol.; (United States), Journal Name: J. Neuropathol. Exp. Neurol.; (United States) Vol. 39:5; ISSN JNENA
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRAL CORTEX
CEREBRUM
COBALT 60
COBALT ISOTOPES
ELECTROMAGNETIC RADIATION
EVALUATION
EXTERNAL IRRADIATION
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONKEYS
NERVE CELLS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PRENATAL EXPOSURE
PRENATAL IRRADIATION
PRIMATES
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SOMATIC CELLS
VERTEBRATES
WHOLE-BODY IRRADIATION
YEARS LIVING RADIOISOTOPES