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Radioimmunoassay for human pancreatic ribonuclease and measurement of serum immunoreactive pancreatic ribonuclease in patients with malignant tumors

Journal Article · · Cancer Res.; (United States)
OSTI ID:6879948
; ; ; ; ; ; ; ; ;
A method for radioimmunoassay of human pancreatic RNase was developed. The method is sensitive, reproducible, and specific. Almost no cross-reactivity exists between human pancreatic and liver RNases. A good correlation was observed between the serum concentration of pancreatic RNase as measured by radioimmunoassay and its enzymatic activity using polycytidylic acid as substrate. The concentration of serum pancreatic RNase correlates well with age, blood urea nitrogen, and albumin contents but does not correlate with serum amylase activity. Using the data of 52 patients with malignant tumors except pancreatic cancer, serum RNase level could be expressed by a multiple regression equation: Immunoreactive RNase content in pancreatic cancer was elevated in patients with complications from renal failure. Serum pancreatic RNase contents in patients with pancreatic cancer measured by radioimmunoassay agreed well with the values calculated using the equation derived from the data of patients with other malignant tumors.
Research Organization:
Second Department of Surgery, Osaka University Medical School, Japan
OSTI ID:
6879948
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 44:5; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD CHEMISTRY
BODY
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
ENZYME ACTIVITY
ENZYMES
ESTERASES
GLANDS
HYDROLASES
IODINE ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
NEOPLASMS
ORGANS
PANCREAS
PATIENTS
PHOSPHODIESTERASES
RADIOASSAY
RADIOIMMUNOASSAY
RNA-ASE
TRACER TECHNIQUES