Uranium pinhole collimators for I-131 SPECT imaging

Journal Article · Sun Aug 01 04:00:00 EDT 1999 · IEEE Transactions on Nuclear Science

DOI:https://doi.org/10.1109/23.790851· OSTI ID:687373

Tenney, C R; Greer, K L; Jaszczak, R J ^[1]; Smith, M F ^[2]

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1. Duke University Medical Center, Durham, NC (United States)
2. National Institutes of Health, Bethesda, MD (United States)

Pinhole apertures made of depleted uranium were evaluated for high-resolution SPECT brain tumor imaging of therapeutic doses (30--100 mCi) of intratumorally administered I-131 radiolabeled monoclonal antibodies. High resolution is required for imaging residual tumor tissue, although for therapeutic doses, high collimator sensitivity is less important. Resolution of uranium and tungsten pinhole apertures was compared in planar and SPECT images of I-131 sources. Planar sensitivity was studied on- and off-axis. On-axis planar resolution for uranium pinholes is higher than that of tungsten pinholes for all cases examined; full-width-half-max (FWHM) is narrower for a 3 mm uranium pinhole than for a 1 mm tungsten pinhole, indicating significantly lower penetration at pinhole edges for uranium than for tungsten. Collimator sensitivity is higher for tungsten than for uranium, which also indicates higher edge penetration for tungsten. On-axis SPECT (14.4 cm radius) scans also show better resolution for a 2 mm uranium pinhole (7.8 mm FWHM) than for a 2 mm tungsten pinhole (9.5 mm FWHM). Background radiation from a uranium collimator (102 cts/sec) is acceptably low compared to expected clinical count rates.

• Sponsoring Organization: USDOE, Washington, DC (United States); National Cancer Inst., Bethesda, MD (United States)
• DOE Contract Number: FG02-96ER62150
• OSTI ID: 687373
• Report Number(s): CONF-981110--
• Journal Information: IEEE Transactions on Nuclear Science, Journal Name: IEEE Transactions on Nuclear Science Journal Issue: 4Pt2 Vol. 46; ISSN 0018-9499; ISSN IETNAE
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BRAIN
COLLIMATORS
DEPLETED URANIUM
IMAGE PROCESSING
IODINE 131
NEOPLASMS
RADIOIMMUNOTHERAPY
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SPATIAL RESOLUTION