Pinhole aperture design for {sup 131}I tumor imaging

Conference · Tue Dec 31 04:00:00 EST 1996

OSTI ID:513159

Smith, M F; Jaszczak, R J ^[1]; Wang, Huili ^[2]

---

1. Duke Univ., Durham, NC (United States)
2. Duke Univ. Medical Center, Durham, NC (United States)

A new pinhole aperture design for single photon imaging is introduced whose distinctive feature is a channeled aperture. This allows greater attenuation near the pinhole aperture which is especially important when imaging {sup 131}I with its medium and high energy emissions. Point source response functions were simulated for pinhole inserts with different pinhole diameters (0.4 - 2.0 mm diameter) and channel heights (0.1 - 3.0 mm) with acquisition parameters appropriate for {sup 131}I brain tumor imaging. A photon transport simulation code was used to comprehensively model photon transport and detection. Tradeoff curves between resolution and sensitivity suggest that varying pinhole diameter and channel height to achieve higher resolution at the expense of decreased sensitivity may be advantageous for imaging tumors with intratumoral administration of {sup 131}I radiolabeled monoclonal antibodies.

• DOE Contract Number: FG02-96ER62150
• OSTI ID: 513159
• Report Number(s): CONF-961123--; CNN: Grant R01-CA33541
• Country of Publication: United States
• Language: English

Related Subjects

44 INSTRUMENTATION
INCLUDING NUCLEAR AND PARTICLE DETECTORS
55 BIOLOGY AND MEDICINE
BASIC STUDIES
APERTURES
BRAIN
IMAGE PROCESSING
IODINE 131
NEOPLASMS
RESPONSE FUNCTIONS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TUMOR CELLS