Derivatized gold clusters and antibody-gold cluster conjugates

Patent · Tue Nov 01 00:00:00 EST 1994

OSTI ID:6871214

Hainfeld, J F; Furuya, F R

Antibody- or antibody fragment-gold cluster conjugates are shown wherein the conjugate size can be as small as 5.0 nm. Methods and reagents are disclosed in which antibodies, Fab' or F(ab')[sub 2] fragments are covalently bound to a stable cluster of gold atoms. The gold clusters may contain 6, 8, 9, 11, 13, 55 or 67 gold atoms in their inner core. The clusters may also contain radioactive gold. The antibody-cluster conjugates are useful in electron microscopy applications as well as in clinical applications that include imaging, diagnosis and therapy. 7 figs.

• DOE Contract Number: AC02-76CH00016
• Assignee: Associated Universities, Inc., Washington, DC (United States)
• Patent Number(s): US 5360895; A
• Application Number: PPN: US 7-988338
• OSTI ID: 6871214
• Resource Relation: Patent File Date: 9 Dec 1992
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ANTIBODIES
LABELLING
GOLD ISOTOPES
RADIOIMMUNODETECTION
RADIOIMMUNOTHERAPY
RADIOPHARMACEUTICALS
DIAGNOSTIC TECHNIQUES
DRUGS
IMMUNOTHERAPY
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MEDICINE
NUCLEAR MEDICINE
RADIOLOGY
RADIOTHERAPY
THERAPY
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550201 - Biochemistry- Tracer Techniques