Radioprotection of the intestinal crypts of mice by recombinant human interleukin-1 alpha
- National Institute of Radiological Sciences, Chiba City (Japan)
Recombinant human interleukin-1 alpha (rHIL-1 alpha or IL-1) protected the intestinal crypt cells of mice against X-ray-induced damage. The survival of crypt cells measured in terms of their ability to form colonies of regenerating duodenal epithelium in situ was increased when IL-1 was given either before or after irradiation. The maximum degree of radioprotection was seen when the drug was given between 13 and 25 h before irradiation. The IL-1 dose producing maximum protection was about 6.3 micrograms/kg. This is the first report indicating that the cytokine IL-1 has a radioprotective effect in the intestine. The finding suggests that IL-1 may be of potential value in preventing radiation injury to the gut in the clinic.
- OSTI ID:
- 6869124
- Journal Information:
- Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 123:1; ISSN 0033-7587; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
GROWTH FACTORS
INJURIES
INTESTINES
IONIZING RADIATIONS
LYMPHOKINES
MAMMALS
MICE
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SMALL INTESTINE
SURVIVAL TIME
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DIGESTIVE SYSTEM
ELECTROMAGNETIC RADIATION
GASTROINTESTINAL TRACT
GROWTH FACTORS
INJURIES
INTESTINES
IONIZING RADIATIONS
LYMPHOKINES
MAMMALS
MICE
MITOGENS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION PROTECTION
RADIATIONS
RADIOSENSITIVITY EFFECTS
RODENTS
SMALL INTESTINE
SURVIVAL TIME
VERTEBRATES
X RADIATION