Radiobiology of the rhabdomyosarcoma R1H of the rat: Influence of the size of irradiation field on tumor response, tumor bed effect, and neovascularization kinetics

Journal Article · Sun Apr 01 04:00:00 EDT 1990 · International Journal of Radiation Oncology, Biology and Physics; (USA)

DOI:https://doi.org/10.1016/0360-3016(90)90411-C· OSTI ID:6868563

Wuerschmidt, F B; Beck-Bornholdt, H P; Vogler, H ^[1]

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1. Univ. of Hamburg (Germany, F.R.)

R1H tumors were irradiated with a single dose of 15 Gy X rays using varying sizes of treatment fields. Damage to tumor cells and tumor stroma was determined separately by analysis of growth delay to ten times treatment volume (GD10vo) and net growth delay. GD10vo comprises irradiation effects on tumor parenchymal cells and on tumor stroma, whereas net growth delay only measures effects on tumor parenchymal cells. Stromal damage was observed to increase with increasing field size; the effect on the tumor parenchymal cells, however, was independent of the field size. An increase of GD10vo of 13 days per cm increase of field size diameter was observed. From this the velocity of neovascularization of the irradiated tumor bed was calculated to be 0.30 to 0.38 mm per day.

• OSTI ID: 6868563
• Journal Information: International Journal of Radiation Oncology, Biology and Physics; (USA), Journal Name: International Journal of Radiation Oncology, Biology and Physics; (USA) Vol. 18:4; ISSN 0360-3016; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
DISEASES
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
IONIZING RADIATIONS
IRRADIATION PROCEDURES
MAMMALS
MEDICINE
MYOSARCOMAS
NEOPLASMS
NUCLEAR MEDICINE
RADIATIONS
RADIOLOGY
RADIOTHERAPY
RATS
RHABDOMYOSARCOMAS
RODENTS
SARCOMAS
THERAPY
VERTEBRATES
X RADIATION