Tumor sensitization and protection: influence of stromal injury on estimates of dose modification
Conference
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6264361
Tumor regrowth delay is an assay which reflects tumor cell kill but can be modified by growth rate changes resulting from damage to the stroma (tumor bed effects). If the stromal damage is modified by radiosensitizers and radioprotectors to a different degree from the tumor cells, the overall measurement of dose modifying factors may be influenced by the choice of a regrowth size for the growth delay analysis. The authors have studied the response of two mouse tumors; a fibrosarcoma which showed only a small TBE and a carcinoma which showed a very large TBE. Sensitizer enhancement ratios and protection factors have been obtained by assessing regrowth to a variety of endpoint sizes. The dose modifying effects on the stroma have then been determined by analyzing the regrowth rates of tumors after irradiation. The choice of endpoint size modified both the sensitizer enhancement ratio and the protection factor for both tumors. It appears that stromal damage may be the cause of the radioprotection observed in the carcinoma, whereas direct tumor cell radioprotection is indicated in the fibrosarcoma.
- Research Organization:
- Mount Vernon Hospital, Northwood, England
- OSTI ID:
- 6264361
- Report Number(s):
- CONF-8311204-
- Conference Information:
- Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 10:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
CARCINOMAS
CARDIOVASCULAR SYSTEM
CELL KILLING
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FIBROSARCOMAS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
MICE
MISONIDAZOLE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
SARCOMAS
THIOLS
VERTEBRATES
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD VESSELS
BODY
CARCINOMAS
CARDIOVASCULAR SYSTEM
CELL KILLING
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXPERIMENTAL NEOPLASMS
FIBROSARCOMAS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IONIZING RADIATIONS
MAMMALS
MICE
MISONIDAZOLE
NEOPLASMS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RODENTS
SARCOMAS
THIOLS
VERTEBRATES
X RADIATION