Differential response of early erythropoietic and granulopoietic progenitors to dexamethasone and cortisone
Journal Article
·
· J. Exp. Med.; (United States)
The sensitivity of erythropoietic and granulopoietic progenitor cells to dexamethasone and cortisone was studied in cultures of mouse bone marrow. Although the log dose-response relationships had a similar form, the BFU-E were much more sensitive than the CFU-C to either glucocorticoid. These findings suggest a specific rather than a general response to glucocorticoids and indicate that granulocyte-macrophage progenitors are less affected than early erythroid progenitors by physiologic concentrations of these hormones.
- Research Organization:
- Univ. of California, San Francisco
- OSTI ID:
- 6868531
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 149; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550300* -- Cytology
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CFU
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
CORTISONE
DEXAMETHASONE
DOSE-RESPONSE RELATIONSHIPS
ERYTHROCYTES
ERYTHROPOIESIS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
LEUKOCYTES
LEUKOPOIESIS
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
PREGNANES
RODENTS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BLOOD FORMATION
BODY FLUIDS
BONE MARROW CELLS
CELL CULTURES
CFU
CONNECTIVE TISSUE CELLS
CORTICOSTEROIDS
CORTISONE
DEXAMETHASONE
DOSE-RESPONSE RELATIONSHIPS
ERYTHROCYTES
ERYTHROPOIESIS
GLUCOCORTICOIDS
HORMONES
HYDROXY COMPOUNDS
KETONES
LEUKOCYTES
LEUKOPOIESIS
MAMMALS
MATERIALS
MICE
ORGANIC COMPOUNDS
PREGNANES
RODENTS
SOMATIC CELLS
STEROID HORMONES
STEROIDS
VERTEBRATES