Influence of site of regional ischemia on LV cavity shape change in dogs

Journal Article · Tue Mar 01 04:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6867898

Marino, P; Kass, D; Lima, J; Maughan, W L; Graves, W; Weiss, J L ^[1]

---

1. Johns Hopkins Medical Institutions, Baltimore, MD (USA)

The authors assessed whether altering the location of acute ischemia produced differing and consistent changes in cavity shape in the canine left ventricle. Twenty anesthetized open-chest dogs underwent transient occlusion of the left anterior descending (LAD) or circumflex (Circ) artery, and cavity shape change was recorded in two-dimensional short-axis echocardiograms. The extent of injury was assessed by radiolabeled microspheres. Shape was analyzed by converting digitized endocardial contours into polar form and expressing the results as a Fourier series. Series terms reflected specific shape deformations. Normal ventricular shape became more circular during ejection indicated by a reduction in the power in nearly all of the Fourier spectra components. During Circ occlusion, the chamber became more elongated and overall shape significantly less circular at end systole than at end diastole. LAD occlusion produced an entirely different pattern, one with no significant elongation but the development of a more triangular shape by end systole. They conclude that there are characteristic and contrasting shape deformations in LV short-axis contours that depend on the site of ischemic injury. These changes may relate to site-specific geometry and loading, and they point to potential limitations of left ventricular models that no not account for regional inhomogeneity.

• OSTI ID: 6867898
• Journal Information: American Journal of Physiology; (USA), Journal Name: American Journal of Physiology; (USA) Vol. 254:3; ISSN 0002-9513; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CERIUM 141
CERIUM ISOTOPES
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
ELECTROMAGNETIC RADIATION
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FOURIER ANALYSIS
GAMMA RADIATION
GEOMETRY
HEART
INJURIES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MATHEMATICS
MEDICINE
MICROSPHERES
MINUTES LIVING RADIOISOTOPES
NIOBIUM 95
NIOBIUM ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOGENESIS
RADIATIONS
RADIOASSAY
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RUTHENIUM 103
RUTHENIUM ISOTOPES
SCANDIUM 46
SCANDIUM ISOTOPES
SCINTILLATION COUNTING
SECONDS LIVING RADIOISO
SHAPE
SURGERY
TIN 113
TIN ISOTOPES
ULTRASONOGRAPHY
VASCULAR DISEASES
VERTEBRATES