Left ventricular systolic and diastolic function in hyperthyroidism

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Am. Heart J.; (United States)

DOI:https://doi.org/10.1016/0002-8703(82)90160-0· OSTI ID:6373818

Friedman, M J; Okada, R D; Ewy, G A; Hellman, D J

In order to assess the effect of hyperthyroidism on systolic and diastolic function of the left ventricle, M-mode echocardiograms and systolic time intervals were obtained in 13 patients while they were clinically hyperthyroid and again when they were euthyroid following radioactive iodine therapy. Echocardiographic tracings of the septum and left ventricular posterior wall were digitized and analyzed to provide the maximum velocity of shortening and maximum velocity of lengthening. These velocities were normalized for left ventricular diastolic dimension. The left ventricular minor axis fractional shortening and the normalized maximum velocity of shortening were both increased during the hyperthyroid state. The normalized maximum velocity of lengthening, a measure of diastolic left ventricular function, was also increased during the hyperthyroid state when compared to the euthyroid state. The preejection period index and the preejection period/left ventricular ejection time ratio were lower when the patients were hyperthyroid than when they were euthyroid. These data confirm the increased inotropic state and demonstrated increased diastolic relaxation velocities of the hyperthyroid left ventricle.

• Research Organization: Department of Internal Medicine, University of Arizona College of Medicine
• OSTI ID: 6373818
• Journal Information: Am. Heart J.; (United States), Journal Name: Am. Heart J.; (United States) Vol. 104:6; ISSN AHJOA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD CIRCULATION
BODY
CARDIOVASCULAR SYSTEM
DISEASES
DYNAMIC FUNCTION STUDIES
ENDOCRINE DISEASES
HEART
HYPERTHYROIDISM
IODINE ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
ORGANS
PATHOLOGY
PATIENTS
RADIOLOGY
RADIOTHERAPY
THERAPY