Comparative biochemistry and metabolism. Part I. Carcinogenesis. Annual report Jun 81-May 82
Technical Report
·
OSTI ID:6866159
The inorganic reducing agent, hydrazine, is toxic and weakly carcinogenic. In earlier studies it was found that oral administration of a toxic dose of hydrazine to the rat resulted in methylation of liver DNA guanine moieties with an apparent dependency upon endogenous S-adenosylmethionine as the source of the methyl group. Further studies have been carried out to confirm the identity of these methylated bases in DNA as 7-methylguanine and 06-methylguanine, to determine the rates of their formation and the duration of their persistence in DNA, and to investigate possible mechanisms by which hydrazine might stimulate the methylation of liver DNA.
- Research Organization:
- California Univ., Irvine (USA). Dept. of Community and Environmental Medicine
- OSTI ID:
- 6866159
- Report Number(s):
- AD-A-119124/6
- Country of Publication:
- United States
- Language:
- English
Similar Records
S-adenosylmethionine metabolism and DNA methylation in hydrazine-treated rats
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro
Seven-methylguanine adducts in DNA are normally present at high levels and increase on aging: Analysis by HPLC with electrochemical detection
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· Carcinogenesis (N.Y.); (United States)
·
OSTI ID:5684113
Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro
Journal Article
·
Thu Dec 31 23:00:00 EST 1981
· Carcinogenesis (N.Y.); (United States)
·
OSTI ID:7071743
Seven-methylguanine adducts in DNA are normally present at high levels and increase on aging: Analysis by HPLC with electrochemical detection
Journal Article
·
Sat Oct 01 00:00:00 EDT 1988
· Proceedings of the National Academy of Sciences of the United States of America; (USA)
·
OSTI ID:5608096
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOCHEMISTRY
BODY
CARCINOGENESIS
CHEMICAL REACTIONS
CHEMISTRY
DIGESTIVE SYSTEM
DNA
DRUGS
GLANDS
GLUTATHIONE
GUANINE
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDRAZINE
HYDROXY COMPOUNDS
LIVER
MAMMALS
METABOLISM
METHYLATION
NITROGEN COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDES
POLYPEPTIDES
PROTEINS
PURINES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
TOXICITY
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
BIOCHEMISTRY
BODY
CARCINOGENESIS
CHEMICAL REACTIONS
CHEMISTRY
DIGESTIVE SYSTEM
DNA
DRUGS
GLANDS
GLUTATHIONE
GUANINE
HAMSTERS
HETEROCYCLIC COMPOUNDS
HYDRAZINE
HYDROXY COMPOUNDS
LIVER
MAMMALS
METABOLISM
METHYLATION
NITROGEN COMPOUNDS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOGENESIS
PEPTIDES
POLYPEPTIDES
PROTEINS
PURINES
RADIOPROTECTIVE SUBSTANCES
RATS
RODENTS
TOXICITY
VERTEBRATES