Nonenzymatic methylation of DNA by S-adenosylmethionine in vitro
Journal Article
·
· Carcinogenesis (N.Y.); (United States)
S-Adenosylmethionine was found to methylate DNA non-enzymatically to produce the same putative promutagenic and procarcinogenic lesions formed by carcinogenic chemical methylating agents. The formation of 7-methylguanine was confirmed by u.v. spectrophotometry, the formation of O6-methylguanine and 3-methyladenine was suggested by the cochromatography of radioactivity with standard bases. It is possible that this reaction may explain the presence of constitutive cellular enzymes specifically for the repair of methylated DNA, and may indicate the mechanism whereby methylated guanine is formed in the liver DNA of rats with chemically induced liver damage.
- Research Organization:
- Fels Research Institute, Philadelphia, PA
- OSTI ID:
- 7071743
- Journal Information:
- Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 3:3; ISSN CRNGD
- Country of Publication:
- United States
- Language:
- English
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OSTI ID:5684113
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Related Subjects
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400102 -- Chemical & Spectral Procedures
550201* -- Biochemistry-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADENINES
AMINES
AMINO ACIDS
ANIMALS
ANTIMETABOLITES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CATTLE
CHEMICAL REACTIONS
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DNA
DOMESTIC ANIMALS
DRUGS
ENZYME ACTIVITY
GLANDS
GUANINE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
KINETICS
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
MAMMALS
METHIONINE
METHYLATION
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PURINES
RATS
REACTION KINETICS
RECOVERY
REPAIR
RODENTS
RUMINANTS
SEPARATION PROCESSES
VERTEBRATES
400102 -- Chemical & Spectral Procedures
550201* -- Biochemistry-- Tracer Techniques
550501 -- Metabolism-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADENINES
AMINES
AMINO ACIDS
ANIMALS
ANTIMETABOLITES
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CARBOXYLIC ACIDS
CARCINOGENESIS
CATTLE
CHEMICAL REACTIONS
CHROMATOGRAPHY
DIGESTIVE SYSTEM
DNA
DOMESTIC ANIMALS
DRUGS
ENZYME ACTIVITY
GLANDS
GUANINE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IN VITRO
KINETICS
LABELLED COMPOUNDS
LIPOTROPIC FACTORS
LIQUID COLUMN CHROMATOGRAPHY
LIVER
MAMMALS
METHIONINE
METHYLATION
NUCLEIC ACIDS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PATHOGENESIS
PURINES
RATS
REACTION KINETICS
RECOVERY
REPAIR
RODENTS
RUMINANTS
SEPARATION PROCESSES
VERTEBRATES