Intestinal absorption and retention of /sup 109/Cd: effects of cholecalciferol, calcium status and other variables

Journal Article · Wed Nov 01 04:00:00 EST 1978 · J. Nutr.; (United States)

OSTI ID:6866130

Koo, S I; Fullmer, C S; Wasserman, R H

The intestinal absorption of /sup 109/Cd by chicks was investigated as a function of the site of absorption, absorption period, concentration of stable cadmium, or calcium in the dose, and nutritional status with respect to dietary cholecalciferol, calcium, and phosphorus. All absorption studies utilized the in situ ligated loop technique, and the following observations were made; (a) Duodenal absorption of /sup 109/Cd was approximately 3-fold greater than that in the jejunum or the ileum, with no difference between the latter two. (b) Cadmium absorption in the duodenum occurred in two phases, at an initial rapid rate during the first 20 minutes of absorption, followed by a slow phase thereafter. (c) /sup 109/Cd absorption increased in response to increasing levels of stable Cd in the dosing solution with no evidence for saturation, suggesting that Cd ions may directly affect the permeability characteristics of the epithelial membranes. (d) The absorption of /sup 109/Cd was significantly depressed by 25 mM calcium when present in the ligated loop with a low concentration of cadmium (0.1 mM). However, the absorption was enhanced by the same concentration of calcium when the cadmium concentration in the dose was increased to 1.0 mM. (e) The administration of a single dose of 500 IU of cholecalciferol produced a significant enhancement in /sup 109/Cd absorption. Absorption of /sup 109/Cd was also significantly elevated by dietary calcium or phosphorus deficiency. Nevertheless, a direct involvement of vitamin D-dependent CaBP in cadmium absorption was not indicated as shown by the lack of correlation between the two parameters. (f) The retention of orally administered /sup 109/Cd in the whole body and the gastrointestinal tract diminished with exposure to increasing dietary cadmium.

• Research Organization: Cornell Univ., Ithaca, NY
• DOE Contract Number: EY-76-S-02-2792
• OSTI ID: 6866130
• Journal Information: J. Nutr.; (United States), Journal Name: J. Nutr.; (United States) Vol. 108:11; ISSN JONUA
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALKALINE EARTH METALS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIRDS
CADMIUM 109
CADMIUM ISOTOPES
CALCIUM
CHICKENS
CHOLECALCIFEROL
DOSE-RESPONSE RELATIONSHIPS
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
EVEN-ODD NUCLEI
FOWL
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPES
METALS
NONMETALS
NUCLEI
NUTRITIONAL DEFICIENCY
PHOSPHORUS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RESPONSE MODIFYING FACTORS
RETENTION
UPTAKE
VERTEBRATES
VITAMIN D
VITAMINS
YEARS LIVING RADIOISOTOPES