Disposition of inhaled 1-chloro-2-propanol in F344/N rats
Propylene chlorohydrins, of which 1-chloro-2-propanol (1-CP) is a constituent, used as intermediates in the manufacture of propylene oxide and have been identified as potential air pollutants. The objective of these studies was to determine whether changes in the inhaled exposure concentration would affect the disposition of 1-CP in rats. In addition, experiments were conducted to identify the carbon atom of 1-CP that is metabolized to CO2. Rats were exposed nose-only to (14C)1-CP for 6 hr to 8.3 +/- 1.0 ppm (26.1 +/- 3.2 micrograms/liter air) or 77 +/- 4 ppm (245 +/- 13 micrograms/liter air) (mean +/- SE). There were two major routes of elimination of 14C, urinary and exhalation of CO2, which together accounted for about 80% of the total 14C in excreta and carcass. Half-times for elimination of 14C in urine as 14CO2 were between 3 and 7 hr with no effect of exposure concentration on the elimination half-times for either route. After the end of exposure, kidneys, livers, trachea, and nasal turbinates contained high concentrations of (14C)1-CP equivalents at both exposure concentrations (30-50 nmol 14C/g tissue for the 8 ppm exposure level and 200-350 nmol 14C/g tissue for the 80 ppm exposure level). Elimination of 14C from tissues was biphasic with about 50% of the material in a tissue being rapidly eliminated with a half-time of 1 to 3 hr and the remaining material slowly eliminated with a half-time of 40 to 80 hr. There was no effect of exposure concentration on elimination half-times in tissues. Major metabolites detected in urine and tissues (liver, kidney, and lung) were N-acetyl-S-(hydroxypropyl)cysteine and/or S-(2-hydroxypropyl)-cysteine. Little unmetabolized 1-CP (less than 1%) was detected in analyzed tissues or urine.
- Research Organization:
- Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM (USA)
- OSTI ID:
- 6864668
- Journal Information:
- Toxicol. Appl. Pharmacol.; (United States), Vol. 95:3
- Country of Publication:
- United States
- Language:
- English
Similar Records
Disposition and metabolism of 2,3-( UC)dichloropropene in rats after inhalation
Effect of vapor concentration on the disposition of inhaled 2,3-dichloropropene in Fischer-344 rats
Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ORGANIC CHLORINE COMPOUNDS
METABOLISM
BILE
BIOLOGICAL HALF-LIFE
CARBON 14 COMPOUNDS
CARBON DIOXIDE
INHALATION
METABOLITES
PROPANOLS
RATS
TRACER TECHNIQUES
ALCOHOLS
ANIMALS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
HYDROXY COMPOUNDS
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques