Interactive effects of morphine and ionizing radiation on the latency of tail-withdrawal from warm water in the rat
Technical Report
·
OSTI ID:6864289
The analgesic effect of morphine was enhanced in rats exposed to ionizing radiation (250-5000) in a dose-dependent manner. This was indicated by an increase in the latency of tail-withdrawal from warm water, compared with animals receiving morphine alone. Radiation alone had no effect on latencies or on gross behavior. The enhancing effect of radiation was strongest at 24 hours after irradiation and was partially reversible with naloxone, an opiate antagonist, at a dose of 2 mg/kg, i.m. No changes in survival time after irradiation were noted between animals receiving morphine and those receiving saline injections. The results of this study suggest that the effect of narcotic analgesics to relieve pain in casualties on a nuclear battlefield may be enhanced depending on the postirradiation interval.
- Research Organization:
- Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
- OSTI ID:
- 6864289
- Report Number(s):
- AD-P-003251/6
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
ANALGESICS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
MAMMALS
MEDICINE
MORPHINE
NARCOTICS
OPIUM
ORGANIC COMPOUNDS
PAIN
PHYSICAL PROPERTIES
PREVENTIVE MEDICINE
RADIATION EFFECTS
RATS
RODENTS
SYMPTOMS
SYNERGISM
VERTEBRATES
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALOIDS
ANALGESICS
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DRUGS
MAMMALS
MEDICINE
MORPHINE
NARCOTICS
OPIUM
ORGANIC COMPOUNDS
PAIN
PHYSICAL PROPERTIES
PREVENTIVE MEDICINE
RADIATION EFFECTS
RATS
RODENTS
SYMPTOMS
SYNERGISM
VERTEBRATES