Radiolabeled porphyrin versus gallium-67 citrate for the detection of human melanoma in athymic mice
We performed the biodistribution and imaging studies of /sup 111/In and /sup 67/Ga labeled tetra(4-N-methylpyridyl) porphine, (T4NMPYP), and compared it to that of /sup 67/Ga citrate in athymic mice bearing a human melanoma xenograft. The biodistribution results of both /sup 111/In and /sup 67/Ga labeled T4NMPYP (3, 6, 24, and 48 hours) were similar but differed from that of /sup 67/Ga citrate (48 hours). The optimum tumor uptake of both radiolabeled porphyrins was at 6 hours postinjection and was lower than the tumor uptake of /sup 67/Ga citrate at 48 hours postinjection. Kidney was the only organ showing higher uptake of radiolabeled porphyrin compared to that of /sup 67/Ga citrate. The imaging studies performed with /sup 111/In T4NMPYP and /sup 67/Ga citrate correspond to the biodistribution results. Osteomyelitis present in one mouse showed good localization of /sup 111/In T4NMPYP. 15 refs., 3 figs., 5 tabs.
- Research Organization:
- Yale Univ., New Haven, CT (USA). School of Medicine
- DOE Contract Number:
- AC02-78EV04625
- OSTI ID:
- 6864198
- Report Number(s):
- CONF-870613-1; ON: DE88017251
- Resource Relation:
- Conference: 34. annual meeting of the Society of Nuclear Medicine, Toronto, Canada, 2 Jun 1987; Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GALLIUM 67
SPATIAL DISTRIBUTION
INDIUM 111
COMPARATIVE EVALUATIONS
DIAGNOSIS
EXPERIMENTAL NEOPLASMS
IMAGE PROCESSING
MICE
NEOPLASMS
PORPHYRINS
TISSUE DISTRIBUTION
TRANSPLANTS
UPTAKE
ANIMALS
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROCESSING
RADIOISOTOPES
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics