Comparison of gallium-67 versus indium-111 monoclonal antibody (96. 5, ZME-018) in detection of human melanoma in athymic mice

Journal Article · Tue Sep 01 04:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6245427

Chan, S M; Hoffer, P B; Maric, N; Zoghbi, S S; Kirkwood, J M; Ernstoff, M S; Duray, P H; Gerich, B

We compared the biodistribution of two radiolabeled, whole, tumor selective monoclonal antibodies (( /sup 111/In)96.5, (/sup 111/In)ZME-018) to /sup 67/Ga in nude mice bearing a human melanoma known to express p97 antigen. Localization of gallium was determined 48 hr following i.v. injection. Localization of the radiolabeled antibodies was determined at 3 days and 7 days following i.v. injection. All agents showed more or less similar absolute tumor uptake which varied between 22% and 36% of the injected dose per gram of tumor. Only the tumor uptake of (/sup 111/In)96.5 antibody at 7 days was significantly lower than the /sup 67/Ga uptake at 48 hr. However, uptake in normal tissues was generally higher for both antibodies at 3 and 7 days than for /sup 67/Ga uptake at 48 hr. Therefore, the tumor-to-blood ratio for /sup 67/Ga was tenfold higher than that for either antibody, the tumor-to-muscle ratio was twofold higher. Bone was the only organ in which the tumor-to-organ ratio was consistently higher with radiolabeled antibody than with /sup 67/Ga. The tumor-to-liver and tumor-to-intestine ratios were comparable. Localization of the two tumor selective antibodies was greater than a nonspecific control antibody (( /sup 111/In)CEA) and change in specific activity from 0.17 mCi/mg to 3.3 mCi/mg did not influence localization. From these animal data it may be anticipated that tumor imaging with (/sup 111/In)96.5 or (/sup 111/In)ZME-018 will not be superior to imaging with 67Ga for detection of melanoma.

• Research Organization: Yale Univ. School of Medicine, New Haven, CT
• OSTI ID: 6245427
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 28:9; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
COMPARATIVE EVALUATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EXPERIMENTAL NEOPLASMS
GALLIUM 67
GALLIUM ISOTOPES
INDIUM 111
INDIUM ISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MAN
MELANOMAS
MICE
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIOISOTOPES
RODENTS
TISSUE DISTRIBUTION
TRANSPLANTS
VERTEBRATES