Cadmium and zinc distribution in cardiovascular and other tissues of normal and cadmium-treated dogs
Journal Article
·
· Exp. Mol. Pathol.; (United States)
Cadmium, zinc and water concentrations in arterial segments from 11 different sites - heart, kidney cortex and medulla, liver, spleen, diaphragm, rib and sternum - of eight normal control and eight cadmium-treated dogs were compared. Cadmium treatment resulted in significant cadmium deposition in all of the tissues analyzed. Cardiovascular cadmium distribution in normal and treated dogs revealed higher cadmium levels in more peripheral and smaller arteries in comparison with the more central arteries and the myocardium. The distal mesenteric artery, mesenteric artery branches, main renal artery and coronary arteries tended to accumulate more cadmium in normal or cadmium-treated dogs or both. Zinc distribution in cardiovascular tissues revealed the highest zinc concentration in the mesenteric artery branches of normal dogs. Cadmium was, however, preferentially retained by the normal kidney and by the kidney and liver of cadmium-treated dogs. There were significant increases in zinc concentration of the kidney, liver and sternum in response to cadmium administration. Tissue cadmium/zinc ratio increased by a factor of 7.0-282.6 after cadmium administration. There were no significant alterations in the water content of the cadmium-treated tissues. The pathophysiological implications of these data in cadmium-induced hypertension are discussed.
- Research Organization:
- Washington Univ. School of Medicine, St. Louis, MO
- OSTI ID:
- 6863261
- Journal Information:
- Exp. Mol. Pathol.; (United States), Journal Name: Exp. Mol. Pathol.; (United States) Vol. 22:3; ISSN EXMPA
- Country of Publication:
- United States
- Language:
- English
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