Cardiovascular actions of cadmium at environmental exposure levels

Journal Article · Fri Aug 27 04:00:00 EDT 1982 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.6213041· OSTI ID:6652440

Kopp, S J; Glonek, T; Perry, Jr, H M; Erlanger, M; Perry, E F

A low intake of dietary cadmium induces specific dose-dependent functional and biochemical changes in the cardiovascular tissues of rats. Maximum changes occur when the cadmium intake is 10 to 20 micrograms per kilogram of body weight per day. The changes reflect the accumulation of critical concentrations of cadmium in the cardiovascular tissues. The biologic activity of cadmium is demonstrated for intakes that approach those of the average American adult exposed to the usual environmental concentrations of the element but not to industrial concentrations. The sensitivity of the cardiovascular system to low doses of cadmium could not be anticipated by extrapolation from data on exposure to high concentrations of cadmium. The data support the hypothesis that ingested or inhaled environmental cadmium may contribute to essential hypertension in humans.

• Research Organization: Nuclear Magnetic Resonance Laboratory, Chicago College of Osteopathic Medicine, Illinois
• OSTI ID: 6652440
• Journal Information: Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Journal Issue: 4562 Vol. 217:4562; ISSN SCIEA
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOCHEMISTRY
BIOLOGICAL EFFECTS
CADMIUM
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CHEMISTRY
DIET
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
HYPERTENSION
MAMMALS
METALS
PATHOLOGY
RATS
RODENTS
SENSITIVITY
SYMPTOMS
TOXICITY
VASCULAR DISEASES
VERTEBRATES