Regional cerebral blood flow (RCBF) measurements by SPECT analysis of Xenon-133 transit: Validation of technique and clinical correlation

Conference · Sun Jan 01 04:00:00 EST 1984 · J. Nucl. Med.; (United States)

OSTI ID:6861868

Rezai, K; Kirchner, P; Armstrong, C; Ehrhardt, J; Damasio, H; Adams, H; Damasio, A

The SPECT system (Tomomatic-64) developed by a previous study for rCBF measurements with Xe-133 was validated with phantom simulations and clinical studies. A bi-compartmental flow phantom was developed consisting of a Xenon-133 pump connected in series to head and lung compartments. Flow rates between 0.2 and 1.4 brain volumes/min (20-140 cc/100ml/min) were tested against Tomomatic measurements by linear regression. Correlation was excellent (r=1.0) in the range of 0.2-1.2 (20-120 cc/100ml/min), representing flow rates which are most likely to be encountered in clinical studies. Flow rates above 1.2 (120 cc/100 ml/min) were significantly underestimated. 32 studies on 20 volunteers gave a mean normal flow of 72 (SD=12) cc/ 100g/min. Mean regional flow ranged from 62 in frontal lobes to 75 in central gray matter. Right-to-left variation was less than 5%. The lowest regional flow in a normal subject was 45 cc/100g/min. 68 studies were performed on 30 stroke patients. In 27 rCBF was less than 45 in affected brain areas for a sensitivity of 90% which improved to 97% when comparisons with contralateral brain were included. Initial CT scans were normal or non-diagnostic in 10, but showed CVA's in regions of reduced rCBF in 17 patients. rCBF abnormalities involved greater portions of brain than CT changes, often (8/17) including distant regions, unpredicted by CT or clinical studies but known to be strongly interconnected to the area of structural damage. SPECT estimates of rCBF appear to be a sensitive research and diagnostic tool and complement the structural information provided by CT.

• Research Organization: Univ. of Iowa, Iowa City, IA
• OSTI ID: 6861868
• Report Number(s): CONF-840619-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 25:5
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CAT SCANNING
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVALUATION
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SENSITIVITY
SIMULATION
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE
XENON 133
XENON ISOTOPES