Regional cerebral blood flow abnormalities in Alzheimer's Disease
Conference
·
· J. Nucl. Med.; (United States)
OSTI ID:6699410
In 37 patients (ages 58-81) with senile dementia of Alzheimer type (SDAT), regional cerebral blood flow (rCBF) was studied utilizing a dedicated SPECT system (Tomomatic-64) that produces rCBF images from 4-minute clearance of Xenon-133 in the brain. The authors have modified the device to acquire 5 continuous tomographic slices simultaneously. A consistent pattern of diminished blood flow was seen in 33 patients in the posterior-temporal and lower-parietal brain regions. Computer programs were developed to quantitate the size of the affected brain tissue in the posterolateral brain areas (confined to the posterior 40% and the lateral 25% of the major and minor brain axes respectively). They have previously reported normal rCBF in 25 volunteers to be greater than 45 ml/min/100g with less than 10% regional variation. Hence, an area was considered abnormal if rCBF measured less than 40 ml/min/100g or was less than 70% of the mean rCBF value in the anterior temporal-frontal regions.
- Research Organization:
- Univ. of Iowa, Iowa City, IA
- OSTI ID:
- 6699410
- Report Number(s):
- CONF-850611-
- Conference Information:
- Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550602* -- Medicine-- External Radiation in Diagnostics-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
CLEARANCE
COMPUTER CODES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEASURING METHODS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TOMOGRAPHY
USES
XENON 133
XENON ISOTOPES
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
CLEARANCE
COMPUTER CODES
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEASURING METHODS
NERVOUS SYSTEM
NERVOUS SYSTEM DISEASES
NUCLEI
ORGANS
PATIENTS
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TOMOGRAPHY
USES
XENON 133
XENON ISOTOPES