Interlaboratory comparisons of nickel analyses in urine by atomic absorption spectrometry

Conference · Thu Jun 01 00:00:00 EDT 1978 · Clin. Chem.; (United States)

OSTI ID:6856273

Adams, D B ^[1]; Brown, S S; Sunderman, Jr, F W; Zachariasen, H

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1. INCO Europe Ltd., Swansea, Eng.

Two interlaboratory surveys of urine nickel analyses were performed in which eight or nine urine samples were distributed to laboratories in seven nations for measurements of nickel concentrations by atomic absorption spectrometry. In both surveys, wide discrepancies were observed in the values for urine nickel concentrations that were obtained in different laboratories by various analytical methods. This finding documents a serious need for improvement in the proficiency of nickel analyses. Nonetheless, excellent interlaboratory concordance was found in the rankings of urine samples in order of increasing nickel concentrations. Analytical techniques that involved preliminary wet or dry ashing and extraction steps before flameless atomic absorption spectrometry were generally superior to techniques for direct analysis of urine by flameless atomic absorption spectrometry in respect to (a) analytical sensitivity, (b) recovery of added nickel, (c) interlaboratory precision, and (d) interlaboratory concordance of ranking of urine samples in order of increasing nickel concentrations.

• OSTI ID: 6856273
• Journal Information: Clin. Chem.; (United States), Journal Name: Clin. Chem.; (United States) Vol. 24:6; ISSN CLCHA
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400104* -- Spectral Procedures-- (-1987)
ABSORPTION SPECTROSCOPY
ACCURACY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CHEMICAL ANALYSIS
COMPARATIVE EVALUATIONS
ELEMENTS
ERRORS
METALS
NICKEL
QUANTITATIVE CHEMICAL ANALYSIS
SEPARATION PROCESSES
SPECTROSCOPY
TRACE AMOUNTS
TRANSITION ELEMENTS
URINE
WASTES