Furildioxime method for nickel analysis in serum and urine by electrothermal atomic absorption spectrometry

Conference · Sat Jan 01 04:00:00 EST 1977 · Clin. Chem.; (United States)

OSTI ID:7306880

Mikac-Devic, D ^[1]; Sunderman, Jr, F W; Nomoto, S

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1. Univ. of Zagreb

We describe a method of analysis for nickel in serum and urine. After the sample (1 ml) has been subjected to acid digestion, Ni(II) is extracted into methylisobutylketone as a furildioximate complex, and is measured by electrothermal atomic absorption spectrometry. The method is more sensitive and more convenient than previous methods, and is less subject to nickel contamination because the digestion and extraction steps are performed in a single tube. Analytical recovery of Ni(II) (10 or 20 ..mu..g/liter) added to 20 specimens of serum or urine averaged 101 percent (range, 94 to 107). The following values (mean +- SD) were obtained for nickel concentrations in specimens of serum and urine from 19 healthy adults living in central Connecticut: serum = 3.1 +- 1.6 ..mu..g/liter; urine = 2.7 +- 1.6 ..mu..g/liter. The method provides a practical means for monitoring occupational exposures of workers to nickel compounds.

• OSTI ID: 7306880
• Conference Information: Journal Name: Clin. Chem.; (United States) Journal Volume: 23:6
• Country of Publication: United States
• Language: English

Related Subjects

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400104 -- Spectral Procedures-- (-1987)
550600* -- Medicine
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION SPECTROSCOPY
AMINES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD SERUM
BODY FLUIDS
CHEMICAL ANALYSIS
ELEMENTS
FURANS
FURILDIOXIME
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
METALS
MONITORING
NICKEL
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
OXIMES
PERSONNEL MONITORING
RADIATION MONITORING
REAGENTS
SPECTROSCOPY
TRANSITION ELEMENTS
URINE
WASTES