Progress of renal dysfunction in inhabitants environmentally exposed to cadmium

Journal Article · Sun May 01 04:00:00 EDT 1988 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1988.9934935· OSTI ID:6855910

Kido, T; Honda, R; Tsuritani, I; Yamaya, H; Ishizaki, M; Yamada, Y; Nogawa, K

The reversibility of beta 2-microglobulinuria, glucosuria, and aminoaciduria was examined in 74 inhabitants (32 males and 42 females) over 50 yr of age, who lived in a cadmium-polluted area. The subjects participated in two examinations conducted just after the cessation of cadmium exposure and 5 yr later. All urinary parameters did not show reversible changes. During the 5 yr the geometric mean concentrations of beta 2-microglobulinuria, glucosuria, and aminoaciduria indicated significant increases in excretion. In cases where greater than 1,000 micrograms/g creatinine of beta 2-microglobulinuria was observed (at the time cadmium exposure ended), almost all individuals exposed to cadmium showed deterioration of beta 2-microglobulinuria, whereas in the case of less than 1,000 micrograms/g creatinine of beta 2-microglobulinuria, no significant changes were observed. The present study indicates that cadmium-induced renal dysfunction in individuals environmentally exposed to cadmium is irreversible.

• Research Organization: Kanazawa Medical Univ., Ishikawa (Japan)
• OSTI ID: 6855910
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 43:3; ISSN AEHLA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AZOLES
BODY
CADMIUM
CREATININE
DISEASES
ELEMENTS
ENVIRONMENTAL EXPOSURE
GLYCOSURIA
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IMINES
KIDNEYS
MAMMALS
MAN
METABOLIC DISEASES
METALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
SENSITIVITY
TOXICITY
UROGENITAL SYSTEM DISEASES
VERTEBRATES