Quantitative analysis of normal thallium-201 tomographic studies

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6855358

Eisner, R L; Gober, A; Cerqueira, M; Pettigrew, R; Malko, J A; Plankey, M; Patterson, R; McClees, E; DePuey, E G; Berger, H J

To determine the normal (nl) distribution of Tl-201 uptake post exercise (EX) and at redistribution (RD) and nl washout, Tl-201 rotational tomographic (tomo) studies were performed in 40 subjects: 16 angiographic (angio) nls and 24 nl volunteers (12 from Emory and 12 from Yale). Oblique angle short axis slices were subjected to maximal count circumferential profile analysis. Data were displayed as a ''bullseye'' functional map with the apex at the center and base at the periphery. The bullseye was not uniform in all regions because of the variable effects of attenuation and resolution at different view angles. In all studies, the septum: lateral wall ratio was < 1.0, as was the apex: lateral wall ratio. The anterior: inferior ratio was dependent, in part, upon gender and was > 1.0 in males and approximately equal to 1.0 in females. This occurred predominantly because of anterior defects due to breast soft tissue attenuation. EX and RD bullseyes were similar. Using a bi-exponential model for Tl kinetics, 4 hour normalized washout ranged 49-54% in each group and showed minimal variation between walls throughout the bullseye. Thus, there are well defined variations in Tl-201 uptake in the nl myocardium which must be taken into consideration when analyzing pt data. Because of these defects and the lack of adequate methods for attenuation correction, quantitative analysis of Tl-201 studies must include direct comparison with gender-matched nl data sets.

• Research Organization: Emory Univ., Atlanta, GA
• OSTI ID: 6855358
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
BODY AREAS
CARDIOVASCULAR SYSTEM
CAT SCANNING
CHEST
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DATA ANALYSIS
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELECTRON CAPTURE RADIOISOTOPES
EXERCISE
HEART
HEAVY NUCLEI
IMAGE PROCESSING
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
METABOLISM
MUSCLES
MYOCARDIUM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
OPTIMIZATION
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SEQUENTIAL SCANNING
THALLIUM 201
THALLIUM ISOTOPES
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE