Accuracy of quantitative rotational thallium-201 tomography in identifying individual coronary stenoses: Use of bullseye functional map

Conference · Wed May 01 04:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760310

DePasquale, E E; DePuey, E G; Nody, A; McClees, E C; Eisner, R L; Malko, J; Patterson, R; Pettigrew, R; Berger, H J

To determine the ability of tomographic Tl-201 imaging to localize coronary artery disease (CAD), exercise (EX) and redistribution Tl-201 studies were quantified using maximal count circumferential profiles in 214 patients (pts). Polar coordinate (''bullseye'') images were constructed displaying Tl-201 and 4-hour washout as concentric profiles with the apex at the center and the base of the periphery. Normal (nl) limits were established using 28 nls (12 volunteers and 16 with totally nl angiography). There were 198 pts with > 50% diameter stenosis (DS) (115 l-vessel (v) and 83 multi-v) and 16 with only < 50% DS. The sensitivity and specificity of Tl-201 in identifying individual v were 87% and 90% in l-v and 78% and 86% in multi-v CAD. Only 3% (6/236) of the lesions were detected by slow washout alone. Of 38 false pos defects, 20 were directly contiguous with areas of true abnormality, 5 were in the LCF or RCA, and 4 were in pts with subcritical lesions. In 44% of false neg, EX was < 85% max. Thus, quantitative analysis of tomographic Tl-201 images using circumferential profiles and ''bullseye'' display is a highly sensitive and accurate method for detecting and localizing individual CA stenoses.

• Research Organization: Emory Univ., Atlanta, GA
• OSTI ID: 6760310
• Report Number(s): CONF-850611-
• Conference Information: Journal Name: J. Nucl. Med.; (United States) Journal Volume: 26:5
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BIOLOGICAL LOCALIZATION
BIOMEDICAL RADIOGRAPHY
BLOOD VESSELS
BODY
CARDIOGRAPHY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CAT SCANNING
CHEMICAL ANALYSIS
COMPUTERIZED TOMOGRAPHY
CORONARIES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
IMAGE PROCESSING
IMAGES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
METABOLISM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
QUANTITATIVE CHEMICAL ANALYSIS
RADIOCARDIOGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SENSITIVITY
THALLIUM 201
THALLIUM ISOTOPES
TOMOGRAPHY
USES