Immunoscintigraphic imaging of mIBG-negative metastases in neuroblastoma
- Univ. of Cologne (Germany, F.R.)
We report a study of seven children with recurrent stage IV neuroblastoma comparing the uptake pattern of {sup 123}I-metaiodobenzylguanidine (mIBG) with {sup 99m}Tc-labeled monoclonal antibody (MAb) BW 575 by the tumor lesions. Immunofluorescence studies of bone marrow had verified specific binding of the antibody to the tumor cells. The majority of tumor sites was detected both by mIBG and MAb scans. However, five of 26 lesions were not detected by mIBG and eight of 26 were false negative by immunoscintigraphy. The false negative lesions by mIBG belonged to five different patients (one of five primary, four of five bone marrow). In conclusion, MAb BW 575 may detect mIBG-negative neuroblastoma sites. The presence of antibody-negative sites suggests the utilization of both scintigraphy methods together.
- OSTI ID:
- 6854707
- Journal Information:
- American Journal of Pediatric Hematology/Oncology; (USA), Journal Name: American Journal of Pediatric Hematology/Oncology; (USA) Vol. 12:1; ISSN 0192-8562; ISSN APHOD
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CHILDREN
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
RADIOIMMUNODETECTION
RADIOIMMUNOSCINTIGRAPHY
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
TECHNETIUM 99
TECHNETIUM ISOTOPES
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES