Skeletal assessment in neuroblastoma--the pitfalls of iodine-123-MIBG scans

Journal Article · Wed Jan 31 23:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6854636

Gordon, I; Peters, A M; Gutman, A; Morony, S; Dicks-Mireaux, C; Pritchard, J ^[1]

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1. Hospital for Sick Children, London (England)

This study was carried out to compare iodine-123 metaiodobenzylguanidine ((I123I)MIBG) and technetium-99m-methylene diphosphonate bone scans ({sup 99m}Tc-MDP) in the detection of skeletal involvement by neuroblastoma. Forty-four children with neuroblastoma underwent both ({sup 123}I) MIBG and {sup 99m}Tc-MDP scans within a 4-wk period; bone marrow examination also was performed; all these investigations were done both at diagnosis and at follow-up. At diagnosis, four children with Stage 4 disease had normal ({sup 123}I)MIBG scans but abnormal {sup 99m}Tc-MDP scans, while at follow-up there were four children with negative ({sup 123}I)MIBG studies who later died from disseminated neuroblastoma. All eight scans are considered false-negative. In 24 children, the ({sup 123}I)MIBG revealed more extensive disease with 161 positive sites while the {sup 99m}Tc-MDP scan showed only 100 positive sites; 34 of these sites were common to both studies. This study shows that underassessment of skeletal involvement by neuroblastoma occurred using ({sup 123}I)MIBG scans and that one cannot therefore substitute ({sup 123}I)MIBG for {sup 99m}Tc-MDP bone scans in the staging of neuroblastoma.

• OSTI ID: 6854636
• Journal Information: Journal of Nuclear Medicine; (USA), Journal Name: Journal of Nuclear Medicine; (USA) Vol. 31:2; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AGE GROUPS
ANIMAL TISSUES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BONE MARROW
CHILDREN
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEMATOPOIETIC SYSTEM
HOURS LIVING RADIOISOTOPES
INFANTS
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
SENSITIVITY ANALYSIS
SKELETON
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
YEARS LIVING RADIOISOTOPES