Restricted helper function of F1 leads to parent bone marrow chimeras controlled by K-end of H-2 complex
Journal Article
·
· J. Exp. Med.; (United States)
F1 leads to parent bone marrow chimeras were prepared by transferring F1 hybrid marrow cells into heavily irradiated parental strain mice. When unprimed, donor-derived F1 T cells from the chimeras were activated to sheep erythrocytes (SRC) for 5 days in irradiated normal F1 mice, high IgM and IgG anti-SRC responses were observed with F1 B cells. Significantly, however, responses with B cells of the opposite parental strain were either absent or very low. The restriction in T-helper function mapped to the K-end of the H-2 complex.
- Research Organization:
- Univ. of Pennsylvania, Philadelphia
- OSTI ID:
- 6854096
- Journal Information:
- J. Exp. Med.; (United States), Journal Name: J. Exp. Med.; (United States) Vol. 147:6; ISSN JEMEA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Two subgroups of T helper cells in F/sub 1/ hybrid mice revealed by negative selection to heterologous erythrocytes in vivo. [Gamma radiation]
Restricted antibody formation to sheep erythrocytes of allogeneic bone marrow chimeras histoincompatible at the K end of the H-2 complex
Leucyl-leucine methyl ester treatment of donor cells permits establishment of immunocompetent parent----F1 chimeras that are selectively tolerant of host alloantigens
Journal Article
·
Tue Oct 31 23:00:00 EST 1978
· J. Immunol.; (United States)
·
OSTI ID:6503551
Restricted antibody formation to sheep erythrocytes of allogeneic bone marrow chimeras histoincompatible at the K end of the H-2 complex
Journal Article
·
Tue Mar 31 23:00:00 EST 1981
· J. Exp. Med.; (United States)
·
OSTI ID:5703453
Leucyl-leucine methyl ester treatment of donor cells permits establishment of immunocompetent parent----F1 chimeras that are selectively tolerant of host alloantigens
Journal Article
·
Thu Oct 01 00:00:00 EDT 1987
· J. Immunol.; (United States)
·
OSTI ID:5715052
Related Subjects
551000* -- Physiological Systems
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
GLOBULINS
HYBRIDIZATION
IMMUNOGLOBULINS
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOLECULAR STRUCTURE
MOSAICISM
ORGANIC COMPOUNDS
PROTEINS
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
ANIMALS
BIOLOGICAL MATERIALS
BIOSYNTHESIS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHIMERAS
CONNECTIVE TISSUE CELLS
GLOBULINS
HYBRIDIZATION
IMMUNOGLOBULINS
IMMUNOLOGY
LEUKOCYTES
LYMPHOCYTES
MAMMALS
MATERIALS
MICE
MOLECULAR STRUCTURE
MOSAICISM
ORGANIC COMPOUNDS
PROTEINS
RADIATION CHIMERAS
RODENTS
SOMATIC CELLS
SYNTHESIS
VERTEBRATES