Marrow fat cell: response to x-ray induced aplasia

Journal Article · Tue Sep 11 04:00:00 EDT 1979 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(79)90497-1· OSTI ID:6853747

Bathija, A; Ohanian, M; Davis, S; Trubowitz, S

Adipose tissue is an integral structural component of normal rabbit marrow and is believed to behave primarily as a cushion in response to hemopoietic proliferation, accommodating to changes in hemopoiesis by change in either size or number or both of the fat cells in order to maintain constancy of the marrow volume. To test this hypothesis, aplasia of the right femur of New Zealand white rabbits was induced by x irradiation with 8000 rads; the left unirradiated limb served as control. Twenty-four hours before sacrifice 50 ..mu..Ci of palmitate-114C was administered intravenously and the marrow of both femurs removed. Samples of perinephric fat were taken for comparison. Fat cell volume, C14 palmitate turnover and fatty acid composition were determined. The total number of fat cells in the entire marrow of both femurs was calculated. The measurements showed no difference in size or fatty acid turnover of the fat cells in the irradiated aplastic marrow from the cells of the control marrow. The number of fat cells in both the irradiated and the unirradiated control femurs was essentially the same. These findings do not support the view that marrow fat cells respond to diminished hematopoiesis by either increase in their volume or number. In addition, the findings suggest that both marrow and subcutaneous fat cells are fairly resistant to high doses of x-ray irradiation.

• Research Organization: New Jersey Medical School, Newark
• OSTI ID: 6853747
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 25:11; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADIPOSE TISSUE
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BODY
BODY FLUIDS
BONE MARROW
CARBOXYLIC ACIDS
CONNECTIVE TISSUE
CONNECTIVE TISSUE CELLS
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
FAT CELLS
FEMUR
HEMATOPOIETIC SYSTEM
IONIZING RADIATIONS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
RABBITS
RADIATION DOSES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY
SKELETON
SOMATIC CELLS
TISSUES
VERTEBRATES
VOLUME
X RADIATION