The correlation between excessive vitreal protein levels, prostaglandin E2 levels, and the blood retinal barrier

Journal Article · Thu Feb 01 04:00:00 EST 1990 · Prostaglandins; (USA)

DOI:https://doi.org/10.1016/0090-6980(90)90071-3· OSTI ID:6852649

Naveh, N; Weissman, C ^[1]

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1. Maurice and Gabriela Goldschleger Eye Research Institute, Tel Hashomer (Israel)

Changes in vitreal protein and prostaglandin E2 (PGE2) concentrations, as well as chorioretinal in vitro PGE2 production, were studied in rabbit eyes following Neodymium (Nd):YAG laser retinal exposure. Laser exposure was associated with an enhanced vitreal PGE2 concentration throughout a two-week observation period, with highest levels on days 1 and 7 after exposure (a 5.3 and 4.7 increase above baseline, respectively). A transitory 50% elevation above baseline in vitreal protein levels was observed in the laser-exposed eyes during the second week after exposure. Laser exposure was also associated with an enhancement in the in vitro chorioretinal PGE2 production, which varied throughout the observation period, and was more pronounced during the first week after exposure, when levels were four times higher than baseline. Initially PGE2 vitreal levels were closely related to excessive in vitro production. However, during the second week after exposure, evidence of such correlation was lacking, but PGE2 vitreal levels coincided with a small increase in vitreal protein levels. It is suggested that disruption of the blood retinal barrier by the long-term exposure to mildly elevated vitreal PGE2 levels was accountable for protein leakage, which might have affected PGE2 removal mechanisms.

• OSTI ID: 6852649
• Journal Information: Prostaglandins; (USA), Journal Name: Prostaglandins; (USA) Vol. 39:2; ISSN PRGLB; ISSN 0090-6980
• Country of Publication: United States
• Language: English

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560400* -- Other Environmental Pollutant Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
BODY
BODY AREAS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
LASER RADIATION
LASERS
MAMMALS
NEODYMIUM LASERS
ORGANIC COMPOUNDS
ORGANS
PROSTAGLANDINS
PROTEINS
RABBITS
RADIATIONS
RETINA
SENSE ORGANS
SENSITIVITY
SOLID STATE LASERS
SYNTHESIS
VERTEBRATES