Radiation necrosis of central nervous system studied by PET
The hypothesis being tested is that radiation necrosis can be separated from regrowth of tumor by comparative studies using tracers which reflect different physiological functions. Nine patients treated for CNS tumors were referred because fo onset of neurologic deterioration and were studied by Rb-82 and 18-FDG using the Donner 280-crystal PET. Ten to 15 mCi of Rb-82 was injected i.v. and three PET sections 1 cm thick collected. Next, 8 to 12 mCi of FDG was injected and dynamic PET was performed at a level of high suspicion. Usually five transverse sections spanning the region of suspected pathology are acquired. Patients with active FDG and Rb accumulation in suspicious anatomical areas were diagnosed as tumor recurrence. Regions of Rb accumulation but no FDG accumulation received a tentative diagnosis of early radiation necrosis. Regions with no tracer accumulation represent either effective treatment or radiation necrosis. Three patients with diagnosis of radiation necrosis without regrowth of tumor have been confirmed by biopsy; four patients with recurrent tumor were correctly diagnosed and the remaining patients are being followed serially and have not yet had a confirmation procedure performed. The criteria for regrowth of tumor appears to be sound, however, lack of tracer uptake cannot be specific for radiation necrosis unless there is a progression in sequential studies. These PET studies have been of substantial aid to the neurosurgeons in planning treatment of brain tumor patients.
- Research Organization:
- Donner Lab., Univ. of Calif., Berkeley, CA
- OSTI ID:
- 6851915
- Report Number(s):
- CONF-850611-
- Journal Information:
- J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 26:5; ISSN JNMEA
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANATOMY
ANTIMETABOLITES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BIOLOGICAL LOCALIZATION
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE 18
FLUORINE ISOTOPES
FLUORODEOXYGLUCOSE
FUNCTIONS
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
INTRAVENOUS INJECTION
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NECROSIS
NEOPLASMS
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
PATHOLOGY
PATIENTS
PLANNING
POSITRON COMPUTED TOMOGRAPHY
RADIOINDUCTION
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RETENTION FUNCTIONS
RUBIDIUM 82
RUBIDIUM ISOTOPES
SURGERY
TISSUE DISTRIBUTION
TOMOGRAPHY
UPTAKE
USES