Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies

Journal Article · Thu Dec 31 23:00:00 EST 1987 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.150.1.189· OSTI ID:5650436

Di Chiro, G; Oldfield, E; Wright, D C; De Michele, D; Katz, D A; Patronas, N J; Doppman, J L; Larson, S M; Ito, M; Kufta, C V

Cerebral necrosis after radiotherapy for brain tumors is being recognized as a problem more common than previously estimated. Distinction between this iatrogenic complication and tumor recurrence cannot be made by either CT or MR imaging. By using positron emission tomography (PET) with /sup 18/F-deoxyglucose (FDG) we were able to reach a diagnosis of radiation necrosis, later verified, in 10 of 95 patients referred for the purpose of differentiating tumor recurrence from necrosis. The critical PET-FDG feature was focal hypometabolism in the area of necrosis, which contrasted with the hypermetabolism associated with the residual/recurrent tumor. In addition, four cases of cerebral necrosis after supraophthalmic, intraarterial chemotherapy (BCNU) were studied with the PET-FDG method. The area of chemotherapy damage was also characterized by marked hypometabolism. Histology revealed both similarities and differences between radio- and chemonecrosis.

• Research Organization: National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD
• OSTI ID: 5650436
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Journal Name: AJR, Am. J. Roentgenol.; (United States) Vol. 150:1; ISSN AAJRD
• Country of Publication: United States
• Language: English

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