Use of O-15 water and C-11 butanol to measure cerebral blood flow (CBF) and water permeability with positron emission tomography (PET)
Tracers used to measure CBF with PET and the Kety autoradiographic approach should freely cross the blood-brain barrier. 0-15 water, which is not freely permeable, may underestimate CBF, especially at higher flows. The authors determined this under-estimation relative to flow measured with a freely diffusible tracer, C-11 butanol and used these data to calculate the extraction (E) and permeability surface area product (PS) for 0-15 water. Paired flow measurements were made with 0-15 water (CBF-wat) and C-11 butanol (CBF-but) in eight normal human subjects. Average CBF-but, 55.6 ml/(min . 100g) was significantly greater than CBF-water, 47.6 ml/(min . 100g). The ratio of regional gray matter (GM) flow to white matter (WM) flow was significantly greater with C-11 butanol, indicating a greater underestimation of CBF with 0-15 water in the higher flow GM. Average E for water was 0.92 in WM and 0.82 in GM. The mean PS in GM, 148 ml/(min . 100g), was significantly greater than in WM, 94 ml/(min . 100g). Simulation studies demonstrated that a measurement error in CBF-wat or CBF-but causes an approximately equivalent error in E but a considerably larger error in PS due to the sensitivity of the equation, PS=-CBF . ln(1-E), to variations in E. Modest errors in E and PS result from tissue heterogeneity that occurs due to the limited spatial resolution of PET. The authors' measurements of E and PS for water are similar to data obtained by more invasive methods and demonstrate the ability of PET to measure brain water permeability.
- Research Organization:
- Washington Univ., School of Medicine, St. Louis, MO
- OSTI ID:
- 6851740
- Report Number(s):
- CONF-850611-; TRN: 87-011085
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
BLOOD-BRAIN BARRIER
PERMEABILITY
BRAIN
AUTORADIOGRAPHY
BLOOD FLOW
METABOLISM
POSITRON COMPUTED TOMOGRAPHY
BUTANOLS
DIAGNOSTIC USES
WATER
MEMBRANE TRANSPORT
BIOCHEMISTRY
CARBON 11
COMPUTERIZED SIMULATION
MAN
OXYGEN 15
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
SPATIAL RESOLUTION
ALCOHOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
RESOLUTION
SIMULATION
TOMOGRAPHY
USES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics
550501 - Metabolism- Tracer Techniques