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Metabolism and macromolecular binding of the carcinogen benzo(a)pyrene and its relatively inert isomer benzo(e)pyrene by hamster embryo cells

Journal Article · · Cancer Res.; (United States)
OSTI ID:6850458
; ;

The metabolism and macromolecular binding of the carcinogen benzo(a)pyrene (B(a)P) and its relatively inert structural isomer benzo(e)pyrene (B(e)P) have been studied in order to determine if a metabolic basis exists for their very different biological activities. B(a)P and B(e)P are metabolized by hamster embryo cells to organic solvent-soluble and water-soluble metabolites. Significant quantitative and qualitative differences are observed in the nature of the metabolites from the different hydrocarbons and the distribution of these metabolites between the cytoplasm and the extracellular medium. B(a)P is metabolized more extensively than B(e)P to both ethyl acetate-soluble and water-soluble metabolites.

Research Organization:
Oak Ridge National Lab., TN
DOE Contract Number:
W-7405-ENG-26
OSTI ID:
6850458
Journal Information:
Cancer Res.; (United States), Journal Name: Cancer Res.; (United States) Vol. 39; ISSN CNREA
Country of Publication:
United States
Language:
English

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Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
560305 -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL PATHWAYS
CARCINOGENESIS
CHEMICAL BONDS
COMPARATIVE EVALUATIONS
CONDENSED AROMATICS
EMBRYONIC CELLS
HAMSTERS
HYDROCARBONS
ISOMERS
MAMMALS
METABOLISM
METABOLITES
ORGANIC COMPOUNDS
PATHOGENESIS
PATHOLOGY
RODENTS
SENSITIVITY
TOXICITY
VERTEBRATES