Relative permeability of retina and retinal pigment epithelium to the diffusion of tritiated water from vitreous to choroid

Journal Article · Sat Nov 01 04:00:00 EST 1986 · Arch. Ophthalmol. (Chicago); (United States)

DOI:https://doi.org/10.1001/archopht.1986.01050230116044· OSTI ID:6847689

Orr, G; Goodnight, R; Lean, J S

The movement of intravitreally injected tritiated water from the vitreous to the choroid was accelerated by the removal of intervening retina. Both rate of transfer and peak choroidal levels of the tracer were increased, but the proportion of the intravitreal dose recovered was unaltered. In contrast, the movement of tritiated water after diffuse damage to the retinal pigment epithelium by sodium iodate was similar to that of control eyes. The main resistance to the diffusion of this tracer from the vitreous to the choroid is the retina. The differential permeability of the retina and the retinal pigment epithelium may have a role in normal retinal adhesion.

• Research Organization: Univ. of Southern California, Los Angeles
• OSTI ID: 6847689
• Journal Information: Arch. Ophthalmol. (Chicago); (United States), Journal Name: Arch. Ophthalmol. (Chicago); (United States) Vol. 11; ISSN AROPA
• Country of Publication: United States
• Language: English

Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADHESION
ANIMALS
BIOLOGICAL MATERIALS
BODY
BODY AREAS
BODY FLUIDS
CHALCOGENIDES
DIFFUSION
EYES
FACE
HEAD
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANS
OXIDES
OXYGEN COMPOUNDS
PERMEABILITY
RABBITS
RETINA
SENSE ORGANS
TRITIUM COMPOUNDS
TRITIUM OXIDES
UVEA
VERTEBRATES