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Distribution and elimination of inhaled phenanthridone in Fischer-344 rats

Journal Article · · J. Toxicol. Environ. Health; (United States)
;
Rats were exposed nose-only to an aerosol of (/sup 14/C) phenanthridone, a mutagenic aza-arene found in coal tar. Tissues, urine, feces, and expired air were collected at specified times and assayed for radioactivity. Radioactivity was rapidly absorbed from the respiratory tract and distributed to all tissues examined. It was rapidly eliminated from tissues (< 80% in 12 h), being concentrated only in the large intestine at later timepoints. Excretion of radioactivity in both feces and urine was complete within 4 d. Virtually none of the dose was eliminated as (/sup 14/C)CO/sub 2/. (/sup 14/C) Phenanthridone was also administered orally to assess its absorption from the gastrointestinal tract. Absorption was nearly complete (83 +/- 6%), indicating that phenanthridone ingested as a result of mucociliary clearance and swallowing, grooming, or coprophagy could also contribute to tissue exposure. These results are similar to those obtained from inhalation studies of other polycyclic aromatic hydrocarbons, indicating that as a class, inhaled polycyclic aromatic hydrocarbons may be rapidly absorbed from the respiratory tract, widely distributed throughout the body, and readily eliminated in both urine and feces.
Research Organization:
Inhalation Toxicology Research Inst., Albuquerque, NM
DOE Contract Number:
AC04-76EV01013
OSTI ID:
6846771
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 12:4-6; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism &amp; Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ANIMALS
AROMATICS
AZAARENES
CARBON 14 COMPOUNDS
CARBON COMPOUNDS
CARBON DIOXIDE
CARBON OXIDES
CHALCOGENIDES
CLEARANCE
COAL TAR
COLLOIDS
DISPERSIONS
DISTRIBUTION
EXCRETION
HETEROCYCLIC COMPOUNDS
INGESTION
INHALATION
INTAKE
LABELLED COMPOUNDS
MAMMALS
MUTAGENS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OTHER ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
RATS
RODENTS
SOLS
TAR
TISSUE DISTRIBUTION
VERTEBRATES