Early alveolar clearance of particles in rabbits undergoing acute and subchronic exposure to ozone

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Fundam. Appl. Toxicol.; (United States)

DOI:https://doi.org/10.1016/0272-0590(86)90156-9· OSTI ID:6846630

Driscoll, K E; Vollmuth, T A; Schlesinger, R B

The concentration-response relationship for changes in early alveolar clearance resulting from O/sub 3/ inhalation were investigated. Groups of five rabbits were exposed to 0.0, 0.1, 0.6, or 1.2 ppm O/sub 3/, 2 hr/day X 1 day; or to 0.0, 0.1, or 0.6 ppm O/sub 3/, 2 hr/day X 13 days. Following the initial O/sub 3/ exposure all rabbits inhaled an aerosol of 85Sr-tagged, 3.0-micron, polystyrene latex particles and particle retention was determined daily for the following 14 days. Single exposures to O/sub 3/ produced a concentration related trend from accelerated clearance at 0.1 ppm to a transient impairment of clearance at 1.2 ppm. Subchronic exposure resulted in a significant acceleration of particle clearance at both 0.1 and 0.6 ppm, with the effect more pronounced at the higher level. These results demonstrate that single or repeated exposure of rabbits to 0.1 ppm O/sub 3/, a level below the current National Ambient Air Quality Standard, produces alterations in early alveolar clearance. The effects observed at higher levels of O/sub 3/ appeared to depend on both the concentration and exposure regime; acute exposures produced a concentration related trend toward an initial retardation of clearance, which was followed by an acceleration in particle removal, while repeated exposures resulted in a persistent acceleration of clearance.

• Research Organization: New York Univ, Medical Center, NY
• OSTI ID: 6846630
• Journal Information: Fundam. Appl. Toxicol.; (United States), Journal Name: Fundam. Appl. Toxicol.; (United States) Vol. 2; ISSN FAATD
• Country of Publication: United States
• Language: English

Related Subjects

551001 -- Physiological Systems-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ALKALINE EARTH ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
CLEARANCE
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
ELASTOMERS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
HOURS LIVING RADIOISOTOPES
INHALATION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LATEX
LUNG CLEARANCE
MACROPHAGES
MAMMALS
NUCLEI
ORGANIC COMPOUNDS
ORGANIC POLYMERS
OZONE
PARTICLES
PARTICULATES
PHAGOCYTES
POLYMERS
RABBITS
RADIOISOTOPES
RUBBERS
SOMATIC CELLS
STRONTIUM 85
STRONTIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES