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Mucociliary clearance from the lungs of rabbits following single and intermittent exposures to ozone

Journal Article · · J. Toxicol. Environ. Health; (United States)
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This study examined the effects of ozone (O/sub 3/) inhalation on mucociliary clearance from the tracheobronchial tree. Rabbits were exposed for 2 h at 0.1, 0.25, and 0.6 ppm or for 2 h/d for 14 consecutive days at 0.25 and 0.6 ppm. Clearance was assessed by measuring the retention of radioactivity tagged, inert tracer particles inhaled immediately after the single 2-h exposure, or 24 h after 2, 7, or 14 of the daily exposures. Single exposures resulted in a concentration-related trend toward retarded particle clearance, with a statistically significant difference occurring after exposure to 0.6 ppm. Intermittent exposures produced no significant change in clearance rate, although there was a suggestion of retarded clearance at early time points at both 0.25 and 0.6 ppm.
Research Organization:
Univ. Medical Center, New York, NY
OSTI ID:
6723786
Journal Information:
J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 20:1-2; ISSN JTEHD
Country of Publication:
United States
Language:
English

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Related Subjects

500200* -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
551001 -- Physiological Systems-- Tracer Techniques
560300 -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CLEARANCE
DOSE-RESPONSE RELATIONSHIPS
EXCRETION
INHALATION
INTAKE
ISOTOPE APPLICATIONS
LUNG CLEARANCE
MAMMALS
OZONE
PARTICLES
PARTICULATES
RABBITS
RETENTION
TIME DEPENDENCE
TOXICITY
TRACER TECHNIQUES
VERTEBRATES