Irradiation for control of hypersplenism and painful splenomegaly in myeloid metaplasia
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
In a large series of patients with myeloid metaplasia seen over 8 years, 25 required treatment for painful splenomegaly. Splenectomy was contra-indicated in fourteen of the patients who received 21 courses of megavoltage splenic irradiation as alternative management. The dose required for long-term palliative effect was usually low, i.e., median dose 600 rad in 9 fractions. Spleen enlargement prior to treatment ranged from 2 cm to 20 cm below the costal margin. All 21 treatments produced palliation of pain and 20 (95%) resulted in reduction of spleen size: 6 complete (28%) and 14 partial (67%) responses lasted from 1 to over 73 months, and in 4 patients, over 24 months. No serious hematologic side effects were encountered. Splenic irradiation in myeloid metaplasia has been reported to be hazardous; however, our experience indicates that cautious irradiation can be a safe and useful therapeutic alternative.
- Research Organization:
- Harvard Medical School, Boston
- OSTI ID:
- 6844889
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 2:11-12; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCOPAL RADIATION EFFECTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD COUNT
BLOOD PLATELETS
BODY
BODY FLUIDS
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
LEUKOCYTES
LOCAL IRRADIATION
MEDICINE
MYELOID LEUKEMIA
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SPLEEN
SPLENOMEGALY
SYMPTOMS
THERAPY
X RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSCOPAL RADIATION EFFECTS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BLOOD COUNT
BLOOD PLATELETS
BODY
BODY FLUIDS
DISEASES
ELECTROMAGNETIC RADIATION
HEMIC DISEASES
IONIZING RADIATIONS
IRRADIATION
LEUKEMIA
LEUKOCYTES
LOCAL IRRADIATION
MEDICINE
MYELOID LEUKEMIA
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SPLEEN
SPLENOMEGALY
SYMPTOMS
THERAPY
X RADIATION